insitro is a data-driven drug discovery and development company that leverages machine learning and high-throughput biology to transform the way medicines are created to help patients. At insitro, we are rethinking the entire drug discovery process, from the perspective of machine learning, human genetics, and high-throughput, quantitative biology. Over the past five decades, we have seen the development of new medicines becoming increasingly more difficult and expensive, leaving many patients with significant unmet need. Were embarking on a new approach to drug development one that leverages machine learning and unique in vitro strategies for modeling disease state and designing new therapeutic interventions. We aim to eliminate key bottlenecks in traditional drug discovery, so we can help more people sooner and at a much lower cost to the patient and the healthcare industry. We believe that by harnessing the power of technology to interrogate and measure human biology, we can have a major impact on many diseases. We invest heavily in cutting edge bioengineering technologies to enable the construction of large-scale, high-quality data sets that are designed specifically to drive machine learning methods. Our first application is to use human genetics, functional genomics, and machine learning to build a new generation of in vitro human cell-derived disease models whose response to perturbation is designed to be predictive of human clinical outcomes. This cannot be done without great people. We are bringing together an outstanding team of people whose expertise spans multiple disciplines - life sciences, machine learning, human genetics, engineering, and drug discovery - and building a unique culture where people from diverse backgrounds work as a single team towards a common goal. We offer opportunities to collaborative people with expertise in life science and computational science. Join us to help bring better health to more people, faster and cheaper.
The Opportunity
The heart of insitros strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish this, we are putting together a team of life scientists with expertise in cellular and biochemical assays.
In this role, the successful candidate will be responsible for the development and execution of mid/high throughput biochemical/cellular assays and mechanistic experimentation to advance early stage drug discovery projects. The candidate will work closely with a team of multidisciplinary scientists to enable key assays/models and studies to advance a diverse portfolio of small molecules targeting neurological and metabolic disorders. We value a highly collaborative working style centered on effective communication and rigorous scientific exploration. If you are a highly motivated teammate with a strong desire to impact patients in diseases related to metabolic disorders, we invite you to consider joining our team!
You will be joining a biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing opportunities for significant impact. You will work closely with a very dedicated team, learn a broad range of skills, and help shape insitros culture, strategic direction, and outcomes. Join us, and help make a difference to patients!
Primary responsibilities:
About You
Compensation & Benefits at insitro
Our target starting salary for successful US-based applicants for this role is $90,000 - $115,000. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
About insitro
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit.
The Opportunity
At insitro, we are trying to greatly increase the success rate of drug development by combining human biology and machine learning, at scale.
To enable that mission we need a software layer that ties together the scientific, automation, and machine learning platforms: that software is our Lab Platform!
Were a team of ~9 engineers with a mission to accelerate the pace of science at insitro.
Projects on our roadmap include building a universal experiment request system, delivering our next-gen experimental design tool, and bringing together all of our experiment data into a searchable umbrella interface. These projects push forward some really cool solutions in robotics, workflow automation, and lab orchestration technology.
What you'll do:
Ship stuff that makes our scientists say OMG, this is amazing, thank you so much!
Collaborate with folks from our Machine Learning, automation, and biology groups
Understand our mission and contribute to our roadmap with your own ideas
Shape our early-ish engineering culture with your ideas
All the normal SWE stuff: write code, review design docs, talk to users, and do code reviews.
Ultimately youll move the needle in a meaningful way for insitro and field of medicine
In return, we will support you by:
Placing a high degree of trust in your ideas and execution
Bringing you up to speed in the domain of drug development
Providing a low-stress work environment
Making ourselves available for collaboration and mentorship
Caring about you as a whole person not a resource
Being a well funded startup with conservative runway
About you:
You have 2-4+ years of experience as a professional software engineer
Youre eager to ship stuff that makes a difference to users
You feel comfortable reasoning about the tradeoffs between quality and speed when building in a startup environment
Youre familiar with the usual SWE things: AWS (or GCP), relational databases, writing design docs, version control, doing code reviews, goofing around on Slack
Nice to have:
Experience with LIMS, automation, or a life sciences domain
Experience with our stack: Django, Flask, FastAPI, SQLAlchemy, React, TypeScript, PostgreSQL, Docker
Compensation & Benefits at insitro
Our target starting salary for successful US-based applicants for this role is $130,000 - $170,000 To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
401(k) plan with employer matching for contributions
Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
Open, flexible vacation policy
Paid parental leave
Quarterly budget for books and online courses for self-development
Support to occasionally attend professional conferences that are meaningful to your career growth and development
New hire stipend for home office setup
Monthly cell phone & internet stipend
Access to free onsite baristas and cafe with daily lunch and breakfast
Access to free onsite fitness center
Commuter benefits
The Opportunity
insitros approach to rethinking drug development applies innovative data science and machine learning, at scale, throughout the discovery process. As a Research Engineer, you will help implement, validate, and deploy our largest and most complex methods and models. We work on a variety of problem domains and datasets, including multi-petabyte collections of high-content biological imaging, genomics, and biomolecular structures. To support insitros work at this scale, our team is passionate about the craft of scientific software engineering, ensuring that our tools, infrastructure, and models are scalable, correct, maintainable, and robust. You will work closely with our data scientists, software engineers, biologists, and laboratory scientists to find opportunities and implement projects that will aid our drug discovery efforts. Typical projects might include onboarding methods from research papers, reducing the cost of training existing models, crafting a framework for benchmarking competing methods, or working alongside scientists to deploy methods at scale. While not required, some knowledge of biological or chemical data is valuable in understanding the unique requirements and applications of ML to biology and drug discovery.
About You
Nice to Have
The Opportunity
The heart of insitros strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish this, we are expanding our team of life scientists to support our bioassay team. We are excited for cell biologists with experience in cell-based assay design and development, particularly in the context of drug discovery, to join our team.
The Scientist I/II will be responsible for the design, development, optimization, and qualification of cell-based assays utilized in arrayed screening, target validation, and drug discovery efforts in neuroscience and metabolic disease. This is a role in the Bioassays & Cell Based Arrayed Screening team and part of our larger Technical Operations department, working closely with our therapeutic areas and drug discovery team to support insitros growing pipeline.
Reporting directly to our Associate Director of Assay Management, the successful candidate will work closely with insitro's multidisciplinary scientists, automation engineers, and chemists to deliver on insitros mission to bring better drugs faster to the patients who can benefit most.
This is an excellent opportunity for someone passionate about therapeutic discovery and making an impact to patients!
Key responsibilities:
You will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitros culture, strategic direction, and outcomes. Join us, and help make a difference to patients!
About You:
Nice to have:
Benefits at insitro
Compensation & Benefits at insitro
Our target starting salary for successful US-based applicants for this role is $115,000-$140,000. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
Our target starting salary for successful US-based applicants for this role is $160,000 - $215,000. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, the level at which they are actually hired, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
The Opportunity
The heart of insitros strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together a team of life scientists with cutting-edge cellular and technological expertise.
As an Associate Scientist, you will be responsible for the operation and execution of workflows on our automation platforms. You will be working on many aspects of iPSC technology such as iPSC automation, cell line maintenance, and differentiation. This role will primarily focus on supporting the day-to-day activities for the set up, operation, and maintenance of our automated cell line management systems. This role provides the opportunity to collaborate with a highly talented multidisciplinary team as you develop cutting-edge activities in a state-of-the-art environment with the aim to accelerate machine learning based drug discoveries.
This role requires someone who is collaborative, organized, technically proficient, can multi-task, enjoys being part of a team, and thrives solving issues in a timely manner. Weekend work will be required.
This is an excellent opportunity for someone passionate about therapeutic discovery and making an impact to patients!
Your primary duties will be to:
About You
Benefits at insitro
The Opportunity
The heart of insitros strategy is the combination and application of machine learning to disease biology at scale, and novel analyses from clinical datasets that address key shortcomings in the target discovery and drug development process. To accomplish that, we are putting together an incredible team of highly talented biologists with a passion for target discovery and advancements, and who want to make a difference to this important problem.
In this leadership role, you will help build the metabolic disease therapeutic area (TA). Our initial efforts have focused on high density clinical and in vitro datasets for NAFLD and liver fat to generate a distinct pipeline of novel targets for therapeutic intervention. Our future efforts aim to expand this approach in the area of obesity and adiposity to use machine learning to glean deeper insights into the biology of these phenotypes on cardiometabolic disease, and the selection of the best genes for advancement as therapeutic targets. While primarily a target discovery role, there will be opportunities to oversee project advancement up to drug candidate nomination and IND.
Your primary responsibilities will be:
You will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitros culture, strategic direction, and outcomes. Join us, and help make a difference to patients and find the next generation of therapeutics!
About You
The Opportunity
The heart of insitro?? strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and drug discovery capabilities that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of highly talented drug discovery scientists who want to make a difference by bringing meaningful and accessible medicines to patients with significant unmet needs. In this role, you will help build the Oligonucleotide platform capabilities at insitro including siRNA, mRNA, ASOs, conjugation and formulation.
Key Responsibilities:
You will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro?? culture, strategic direction, and outcomes. Join us, and help make a difference to patients!
About You
Compensation & Benefits at insitro
Our target starting salary for successful US-based applicants for this role is $235,000 - $300,000. To determine starting pay, we consider multiple job-related factors including a candidate?? skills, education and experience, the level at which they are actually hired, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
In addition, insitro also provides our employees:
#LI-SF1
The Opportunity
The heart of insitro?? strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. Neurodegenerative diseases in particular are an area of great potential to derive therapeutic benefit for patients using insitro?? platform. The Associate Scientist III/Scientist I, Neuroscience will partner with scientific and project teammates to develop and execute mid/high throughput biochemical/cellular assays, in vitro mechanistic experimentation, and explore novel models to advance early targets through our pipeline. The candidate will work closely with a team of multidisciplinary scientists, automation and software and machine learning engineers to enable key assays/models for target validation and prosecution toward drug development goals. We value a highly collaborative working style centered on effective communication to drive results at a fearless pace. If you are a highly motivated individual and teammate with a strong desire to impact patients in diseases related to neuroscience, we invite you to consider joining our team.
You will be joining a biotech startup with long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a versatile team, learn a broad range of skills, and help shape insitro?? culture, strategic direction, and outcomes. Join us, and help make a difference to patients!
Primary Responsibilities
About You
Nice to Have