About insitro

insitro is a data-driven drug discovery and development company that leverages machine learning and high-throughput biology to transform the way medicines are created to help patients. At insitro, we are rethinking the entire drug discovery process, from the perspective of machine learning, human genetics, and high-throughput, quantitative biology. Over the past five decades, we have seen the development of new medicines becoming increasingly more difficult and expensive, leaving many patients with significant unmet need. Were embarking on a new approach to drug development one that leverages machine learning and unique in vitro strategies for modeling disease state and designing new therapeutic interventions. We aim to eliminate key bottlenecks in traditional drug discovery, so we can help more people sooner and at a much lower cost to the patient and the healthcare industry. We believe that by harnessing the power of technology to interrogate and measure human biology, we can have a major impact on many diseases. We invest heavily in cutting edge bioengineering technologies to enable the construction of large-scale, high-quality data sets that are designed specifically to drive machine learning methods. Our first application is to use human genetics, functional genomics, and machine learning to build a new generation of in vitro human cell-derived disease models whose response to perturbation is designed to be predictive of human clinical outcomes. This cannot be done without great people. We are bringing together an outstanding team of people whose expertise spans multiple disciplines - life sciences, machine learning, human genetics, engineering, and drug discovery - and building a unique culture where people from diverse backgrounds work as a single team towards a common goal. We offer opportunities to collaborative people with expertise in life science and computational science. Join us to help bring better health to more people, faster and cheaper.

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Associate Scientist II / III

    • insitro
    • South San Francisco, CA

Description

The Opportunity

The heart of insitros strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish this, we are putting together a team of life scientists with expertise in cellular and biochemical assays.

In this role, the successful candidate will be responsible for the development and execution of mid/high throughput biochemical/cellular assays and mechanistic experimentation to advance early stage drug discovery projects. The candidate will work closely with a team of multidisciplinary scientists to enable key assays/models and studies to advance a diverse portfolio of small molecules targeting neurological and metabolic disorders. We value a highly collaborative working style centered on effective communication and rigorous scientific exploration. If you are a highly motivated teammate with a strong desire to impact patients in diseases related to metabolic disorders, we invite you to consider joining our team!

You will be joining a biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing opportunities for significant impact. You will work closely with a very dedicated team, learn a broad range of skills, and help shape insitros culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

Primary responsibilities:

  • Develop, optimize, and perform cellular assays to support the Metabolic Diseases therapeutic area
  • Culture immortalized, primary (e.g. hepatocytes) and iPSC-derived cells
  • Use molecular biology and functional genomics techniques such as CRISPR and siRNA to evaluate disease biology
  • Conduct imaging-based assays to support the metabolic disease therapeutic area
  • Maintain accurate documentation of experiments in electronic lab notebook (ELN)
  • Collaborate with colleagues on multi-disciplinary project teams to provide scientific/technical contributions and deliver project goals

About You

  • BS/MS in Biochemistry, Cell Biology, Pharmacology or a relevant scientific subject area, with a minimum of two (2) years of drug discovery experience in a biotech/pharmaceutical setting
  • Experience in the development and execution cellular assays using a wide range of experimental methods and detection technologies including advanced microscopy, ELISA, immunofluorescence
  • Hands on experience in culturing liver cells and iPSC differentiation, a plus
  • Proven ability to work in cross-functional teams to advance drug discovery, with excellent organization and communication skills

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $90,000 - $115,000. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits

About insitro

insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit.

About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

Software Engineer - Full Stack

    • insitro
    • South San Francisco, CA

Description

The Opportunity

At insitro, we are trying to greatly increase the success rate of drug development by combining human biology and machine learning, at scale.

To enable that mission we need a software layer that ties together the scientific, automation, and machine learning platforms: that software is our Lab Platform!

Were a team of ~9 engineers with a mission to accelerate the pace of science at insitro.

Projects on our roadmap include building a universal experiment request system, delivering our next-gen experimental design tool, and bringing together all of our experiment data into a searchable umbrella interface. These projects push forward some really cool solutions in robotics, workflow automation, and lab orchestration technology.

What you'll do:

  • Ship stuff that makes our scientists say OMG, this is amazing, thank you so much!

  • Collaborate with folks from our Machine Learning, automation, and biology groups

  • Understand our mission and contribute to our roadmap with your own ideas

  • Shape our early-ish engineering culture with your ideas

  • All the normal SWE stuff: write code, review design docs, talk to users, and do code reviews.

  • Ultimately youll move the needle in a meaningful way for insitro and field of medicine

In return, we will support you by:

  • Placing a high degree of trust in your ideas and execution

  • Bringing you up to speed in the domain of drug development

  • Providing a low-stress work environment

  • Making ourselves available for collaboration and mentorship

  • Caring about you as a whole person not a resource

  • Being a well funded startup with conservative runway

About you:

  • You have 2-4+ years of experience as a professional software engineer

  • Youre eager to ship stuff that makes a difference to users

  • You feel comfortable reasoning about the tradeoffs between quality and speed when building in a startup environment

  • Youre familiar with the usual SWE things: AWS (or GCP), relational databases, writing design docs, version control, doing code reviews, goofing around on Slack

Nice to have:

  • Experience with LIMS, automation, or a life sciences domain

  • Experience with our stack: Django, Flask, FastAPI, SQLAlchemy, React, TypeScript, PostgreSQL, Docker

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $130,000 - $170,000 To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

  • 401(k) plan with employer matching for contributions

  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support

  • Open, flexible vacation policy

  • Paid parental leave

  • Quarterly budget for books and online courses for self-development

  • Support to occasionally attend professional conferences that are meaningful to your career growth and development

  • New hire stipend for home office setup

  • Monthly cell phone & internet stipend

  • Access to free onsite baristas and cafe with daily lunch and breakfast

  • Access to free onsite fitness center

  • Commuter benefits

About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

Senior / Staff Research Engineer - Data Science and ML

    • insitro
    • South San Francisco, CA

Description

The Opportunity

insitros approach to rethinking drug development applies innovative data science and machine learning, at scale, throughout the discovery process. As a Research Engineer, you will help implement, validate, and deploy our largest and most complex methods and models. We work on a variety of problem domains and datasets, including multi-petabyte collections of high-content biological imaging, genomics, and biomolecular structures. To support insitros work at this scale, our team is passionate about the craft of scientific software engineering, ensuring that our tools, infrastructure, and models are scalable, correct, maintainable, and robust. You will work closely with our data scientists, software engineers, biologists, and laboratory scientists to find opportunities and implement projects that will aid our drug discovery efforts. Typical projects might include onboarding methods from research papers, reducing the cost of training existing models, crafting a framework for benchmarking competing methods, or working alongside scientists to deploy methods at scale. While not required, some knowledge of biological or chemical data is valuable in understanding the unique requirements and applications of ML to biology and drug discovery.

About You

  • Ph.D. in computer science, statistics, mathematics, physics, engineering, plus two years additional experience, or equivalent experience (for example, BS plus 7 years experience)
  • Research experience with modern data science techniques; machine learning experience is required, but expertise in other techniques may also be helpful, such as Bayesian inference or probabilistic programming
  • Fluency in one or more general-purpose programming languages (strong preference for experience in scientific Python)
  • Experience working with teams throughout the full lifecycle of designing, implementing, deploying, and maintaining robust scientific software
  • Strong desire to deliver work that aids in pioneering drug discovery!

Nice to Have

  • Experience building, shipping, and benchmarking large-scale ML systems, foundation models, or large language models (LLMs)
  • Experience with data modalities relevant to drug discovery, such as microscopy, genetics, or natural language, including patient records, and scientific literature.
  • Experience working on ML experimentation tooling and platforms
  • Experience working with high-performance computing resources, such as GPU clusters
  • Past experience working on multi-functional teams
  • Previous open-source contributions or publications demonstrating impact in relevant projects
 
Compensation & Benefits at insitro
 
Our target starting salary for successful US-based applicants for this role is $185,000 - $225,600. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 
 
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
 
In addition, insitro also provides our employees:
  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

Scientist I/II, Cell Based Assays

    • insitro
    • South San Francisco, CA

Description

The Opportunity

The heart of insitros strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish this, we are expanding our team of life scientists to support our bioassay team.  We are excited for cell biologists with experience in cell-based assay design and development, particularly in the context of drug discovery, to join our team. 

The Scientist I/II will be responsible for the design, development, optimization, and qualification of cell-based assays utilized in arrayed screening, target validation, and drug discovery efforts in neuroscience and metabolic disease. This is a role in the Bioassays & Cell Based Arrayed Screening team and part of our larger Technical Operations department, working closely with our therapeutic areas and drug discovery team to support insitros growing pipeline. 

Reporting directly to our Associate Director of Assay Management, the successful candidate will work closely with insitro's multidisciplinary scientists, automation engineers, and chemists to deliver on insitros mission to bring better drugs faster to the patients who can benefit most.    

This is an excellent opportunity for someone passionate about therapeutic discovery and making an impact to patients!

Key responsibilities:

  • Design, build, and optimize cell based assays in a variety of cell types (immortalized cell lines, primary cells, iPSCs) and functional readouts
  • Work closely with disease biology specialists, chemists, and automation engineers to achieve standardized, highly reproducible workflows 
  • Engage with CRO partners to manage external assay workflows
  • Author and review SOP, protocols, etc 
  • Maintain excellent records in our ELN 
  • Follow data analysis workflows and ensure data quality
  • Be a subject matter and technical expert for assay development requests from our internal collaborators

You will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitros culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

About You:

  • PhD in cell biology, pharmacology, or related field with up to 5 years of post-graduate experience, or a BS/MS with 8-12 years related experience
  • Extensive experience with culturing mammalian cells (immortalized cell lines, primary cells, iPSCs) in 96 and 384 well-plate formats 
  • Experience with a wide variety of end-point assay techniques including, but not limited to AlphaLisa, MSD, luminescence, or fluorescence based readouts
  • Experience with small molecule and genetic (siRNA, ASO, CRISPR) tools, high content imaging, automated liquid handlers and other laboratory automation tools
  • Familiarity with ELNs (e.g. Benchling, PE Signals, etc) and analysis tools (e.g. PE VitroVivo/Spotfire, GraphPad Prism, etc)
  • Driven by scientific rigor and passion for making a difference in the world

Nice to have:

  • Familiarity with arrayed screening (chemical and genetic) 
  • Previous experience working with and/or managing CROs
  • Knowledge of drug discovery workflows

Benefits at insitro

  • Excellent medical, dental, and vision coverage; insitro pays 100% of premiums for employees
  • Excellent mental health and well-being support
  • Open vacation policy
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
  • Paid parental leave
  • Competitive pay and 401(k) matching

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $115,000-$140,000. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

Lead/Senior ML Scientist for Computer Vision, Microscopy

    • insitro
    • South San Francisco, CA

Description

The Opportunity
Imaging based phenotyping of in-vitro biology is at the heart of insitros efforts to accelerate drug development. At insitro we use machine learning to derive clinically relevant insights from rich datasets generated in-house. 
 
As a machine learning computer vision applied scientist  with emphasis on microscopy you will develop ML methods to process and analyze images from multiple microscopy modalities. You will integrate our in-vitro imaging data to modalities like transcriptomics and human cohort data in order to extract insights about disease mechanisms. You will be part of a cross-functional team of life scientists, bioengineers and machine learning scientists that strive to identify therapeutic targets and develop drugs of high efficacy and low toxicity.
 
You will be joining a vibrant biotech startup that has long-term stability, due to significant funding, and is in a high growth phase. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitros culture, strategic direction, and outcomes. Join us, and help make a difference to patients!
 
 
About You
  • Ph.D. in computer vision, machine learning, computer science or a related discipline, or equivalent practical experience (e.g., a Masters degree plus 2 years of relevant industry experience)
  • Effective in team-based software design and development
  • Demonstrated ability to use and develop cutting edge methods for analyzing imaging data
  • Extensive hands on experience working with microscopy data or similar biomedical or biophysical imaging modalities
  • Experience developing models for diverse computer vision tasks (e.g. segmentation, recognition, classification, domain adaptation) including using modern deep learning frameworks (PyTorch, TensorFlow, Keras, etc)
  • Strong programming skills in Python, including processing TB-scale image datasets 
  • Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions
  • Passion for making a difference in the world
 
Nice to Have
  • Demonstrated ability to write software in a team, industry experience or  substantial involvement with open source projects. 
  • Experience modeling with video or imaging time-series datasets
  • Experience building infrastructure for image preprocessing
  • Experience with microscopy data acquisition 
  • Some understanding of image formation models (Fourier optics)
  • Familiarity with cloud computing services (e.g., AWS or GCP)
  • Experience with database languages (e.g., SQL) 
  • Publication record of meaningful contributions to high-quality work in relevant computer vision, clinical ML, or biomedical venues
  • Proficiency in C++/OpenCV/CUDA, or other compiled, statically-typed languages and related computer vision/graphics libraries
 
Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $160,000 - $215,000. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, the level at which they are actually hired, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

Automation Ops, Associate Scientist I/II

    • insitro
    • South San Francisco, CA

Description

The Opportunity

The heart of insitros strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together a team of life scientists with cutting-edge cellular and technological expertise. 

As an Associate Scientist, you will be responsible for the operation and execution of workflows on our automation platforms. You will be working on many aspects of iPSC technology such as iPSC automation, cell line maintenance, and differentiation. This role will primarily focus on supporting the day-to-day activities for the set up, operation, and maintenance of our automated cell line management systems. This role provides the opportunity to collaborate with a highly talented multidisciplinary team as you develop cutting-edge activities in a state-of-the-art environment with the aim to accelerate machine learning based drug discoveries.

This role requires someone who is collaborative, organized, technically proficient, can multi-task,  enjoys being part of a team,  and thrives solving issues in a timely manner.  Weekend work will be required. 

This is an excellent opportunity for someone passionate about therapeutic discovery and making an impact to patients!

Your primary duties will be to: 

  • Operate complex and integrated robotic systems to manage iPSC production through an automated workflow
  • Identify and report any workflow and production issues.
  • Perform various lab procedures according to insitros operating protocols and safety standards.
  • Maintain operational records through various LIMS platforms
  • Contribute ideas and feedback to continuously improve new or existing processes

About You 

  • Experience working with automation equipment (Hamilton liquid handlers, cell imagers)
  • Demonstrate willingness to learn in a fast-paced production environment
  • Excited about process development and optimization
  • Familiarity with aseptic techniques and operating at high standards of lab safety.
  • Proficient computer skills and ability to learn new software or custom UIs
  • Comfortable working in collaborative and dynamic teams
  • Passion for making a difference in the world 
  • Comfortable working weekends

Benefits at insitro

  • Excellent medical, dental, and vision coverage; insitro pays 100% of premiums for employees
  • Excellent mental health and well-being support
  • Open vacation policy
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
  • Paid parental leave
  • Competitive pay and 401(k) matching
Compensation & Benefits at insitro
 
Our target starting salary for successful US-based applicants for this role is $70,000 - $100,00 To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 
 
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
 
In addition, insitro also provides our employees:
  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

(Sr) Director, Metabolic Disorders

    • insitro
    • South San Francisco, CA

Description

The Opportunity

The heart of insitros strategy is the combination and application of machine learning to disease biology at scale, and novel analyses from clinical datasets that address key shortcomings in the target discovery and drug development process. To accomplish that, we are putting together an incredible team of highly talented biologists with a passion for target discovery and advancements, and who want to make a difference to this important problem. 

In this leadership role, you will help build the metabolic disease therapeutic area (TA). Our initial efforts have focused on high density clinical and in vitro datasets for NAFLD and liver fat to generate a distinct pipeline of novel targets for therapeutic intervention. Our future efforts aim to expand this approach in the area of obesity and adiposity to use machine learning to glean deeper insights into the biology of these phenotypes on cardiometabolic disease, and the selection of the best genes for advancement as therapeutic targets. While primarily a target discovery role, there will be opportunities to oversee project advancement up to drug candidate nomination and IND.

Your primary responsibilities will be:

  • Provide leadership and strategic vision to a cross functional team of disease biologists, cell biologists, data scientists and statistical geneticists to create a portfolio in a growing disease area
  • Manage and motivate a group of PhD level scientists in the metabolic disease functional area
  • Contribute to insitros strategy in metabolic disease focusing on obesity and liver diseases 
  • Conceptualize and design strategies for target discovery using in vitro cellular systems of disease using iPSCs and CRISPR based genomic screening and novel clinical phenotypic strategies to generate high dimensional datasets for analysis by machine learning and statistical genetics
  • Lead efforts to follow up on targets with the goal of producing viable therapeutic interventions 
  • Lead external collaborations with partners and with other organizations and individuals in efforts related to the metabolic disease area

You will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitros culture, strategic direction, and outcomes. Join us, and help make a difference to patients and find the next generation of therapeutics!

 

About You

  • PhD in a biological science related field (Pharmacology, Genetics, Biochem etc.) with 10+ years of industry experience in drug discovery. 
  • A strong scientific track record in metabolic disease, obesity/adiposity or target discovery.
  • Experience managing a high-performance team of scientists, including goal setting, and contributing to a culture of effective, high-quality methods development and reducing those methods to a practical implementation
  • Demonstrated track record of leading cross functional project teams, building partnerships and collaborations with data scientists, computational biologists, and statistical geneticists
  • Capable of communicating effectively and collaborate with people of diverse backgrounds and job functions, including a track record of collaborating with life scientists
  • Strong interpersonal skills that motivates others to excel and achieve their very best

 

Compensation & Benefits at insitro
 
Our target starting salary for successful US-based applicants for this role is $210,000 - $270,000. To determine starting pay, we consider multiple job-related factors including a candidates skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 
 
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
 
In addition, insitro also provides our employees:
  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitros approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

Senior Scientist, Oligonucleotide Therapeutics

    • insitro
    • South San Francisco, CA

Description

The Opportunity 

The heart of insitro?? strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and drug discovery capabilities that address key bottlenecks in the drug development pipeline. To accomplish that, we are putting together an incredible team of highly talented drug discovery scientists who want to make a difference by bringing meaningful and accessible medicines to patients with significant unmet needs. In this role, you will help build the Oligonucleotide platform capabilities at insitro including siRNA, mRNA, ASOs, conjugation and formulation.

Key Responsibilities:

  • Guide oligonucleotide efforts (including tools and therapeutics) in projects as project team member
  • Build insitro?? oligonucleotide capabilities through CRO or industry collaborations
  • Work cross-functionally to drive oligonucleotide projects through different stage gates towards clinical development candidates
  • Deeply engage cross-functionally to evaluate new targets towards drug discovery efforts.

You will be joining a growing biotech startup that has long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro?? culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

About You

  • PhD in organic, peptide or oligonucleotide chemistry, molecular biology or a related discipline with 5+ years of direct experience in oligonucleotide design, synthesis, conjugation and formulation
  • Deep understanding of the oligonucleotide drug discovery process
  • Demonstrated track record of leadership advancing oligonucleotide projects through different stages of drug discovery and early-stage development
  • Proven leadership capabilities in cross-functional teams
  • First hand experience in setting up and using CROs for oligonucleotide drug discovery
  • Track record of innovation and impact on projects through peer-reviewed publication and/or patent applications
  • Excellent written and verbal communication skills across multi-functional teams
  • Intellectual curiosity to push the boundaries of drug discovery
Compensation & Benefits at insitro
 
Our target starting salary for successful US-based applicants for this role is $150,000 - $165,000. To determine starting pay, we consider multiple job-related factors including a candidate?? skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 
 
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
 
In addition, insitro also provides our employees:
  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro?? approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

(Senior) Director, Imaging Machine Learning

    • insitro
    • South San Francisco, CA

Description

The Opportunity
The ability to extract biologically and clinically meaningful signals from high content imaging data is at the heart of insitro?? efforts to rethink drug development. We develop and apply advanced machine learning methods both to microscopy data produced in our in-house lab and to imaging data from human clinical cohorts to construct disease-relevant phenotypes and to identify causal factors for those phenotypes, which help reveal new therapeutic interventions. 
As Head of Imaging you will lead the insitro imaging team within the Machine learning org on its mission to analyze insitro?? image-based datasets, develop cutting edge CV approaches to serve our needs, and contribute engineering artifacts to insitro?? ML platform. You will coordinate a team that develops infrastructure and machine-learning techniques to process both cellular in vitro data and patient medical images, in order to further insitro?? mission. You will also work closely with a cross-functional team of life scientists, statistical geneticists, bioengineers, computer vision scientists, genomics scientists, medical scientists, and software engineers to integrate human-level data with our high-throughput in-house in vitro genomic and phenotypic data, with the goal of identifying therapeutic targets and developing drugs that have high efficacy and low toxicity.
 
In this role, you will:
  • Lead and grow a team of outstanding machine learning imaging scientists
  • Guide your team to develop and deploy ML to analyze data from diverse imaging modalities, ranging from fixed and live cell microscopy to histopathology to MRI
  • Onboard and build on state of the art computer vision methods, while also bringing in an understanding of the unique needs of biomedical imaging modalities
  • Lead yearly and quarterly planning, set impactful goals, and align with with cross-functional stakeholders
  • Engineer robust, reusable platform components in partnership with the software engineering team
  • Work with biologists and automation engineers to design experiments that generate datasets that are fit for purpose for machine learning, including ones generated explicitly for training ML models
  • Work with the corporate development and strategy teams to acquire relevant external data sets
  • Collaborate with colleagues working on complementary data modalities (??mics, clinical annotations, etc) to help produce a holistic, multimodal view on human disease stat
You will be joining a vibrant biotech startup that has long-term stability, due to significant funding, and is in a high growth phase. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro?? culture, strategic direction, and outcomes. Join us, and help make a difference to patients!
 
This role is preferably based in the San Francisco Bay Area or Boston, but we are open to discussing other locations in the United States and the UK.
 
 
About You
  • Ph.D. in machine learning, computer vision, computer science, or a related discipline, or equivalent practical experience
  • 5+ years experience working in industry and managing projects and deliverables
  • Experience and demonstrated ability to build and lead teams of engineers and scientists, including recruiting and mentoring team members
  • Demonstrated ability to architect and build reusable code infrastructure and work with engineering teams
  • Demonstrated ability to use and develop cutting edge computer vision methods inspired by real problems
  • Demonstrated ability to work with and analyze medical imaging data (e.g., histopathology), cell imaging data, or ideally both
  • Experience in modern representation learning topics such as self-supervised learning, transfer learning, multi-modal modeling, few-shot learning, robustness and interpretability, uncertainty estimation, and more
  • Experience using modern deep learning frameworks (PyTorch, Jax, etc)
  • Proficiency in Python
  • Ability to communicate effectively and collaborate with people of diverse backgrounds and job functions
  • Passion for making a difference in the world
 
Nice to Have
  • Publication record in high profile venues in machine learning, computer vision, or life sciences
  • High profile venues in machine learning, computer vision, or life sciences
  • Familiarity with cloud computing services (e.g., AWS or GCP)
  • Exposure to basic concepts in biology or medicine
  • Proficiency in scientific engineering and modern engineering practice

 

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $235,000 - $300,000. To determine starting pay, we consider multiple job-related factors including a candidate?? skills, education and experience, the level at which they are actually hired, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits

#LI-SF1

About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro?? approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .

Associate Scientist III/Scientist I, Neuroscience

    • insitro
    • South San Francisco, CA

Description

The Opportunity

The heart of insitro?? strategy is the development of novel, innovative methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. Neurodegenerative diseases in particular are an area of great potential to derive therapeutic benefit for patients using insitro?? platform. The Associate Scientist III/Scientist I, Neuroscience will partner with scientific and project teammates to develop and execute mid/high throughput biochemical/cellular assays, in vitro mechanistic experimentation, and explore novel models to advance early targets through our pipeline. The candidate will work closely with a team of multidisciplinary scientists, automation and software and machine learning engineers to enable key assays/models for target validation and prosecution toward drug development goals. We value a highly collaborative working style centered on effective communication to drive results at a fearless pace. If you are a highly motivated individual and teammate with a strong desire to impact patients in diseases related to neuroscience, we invite you to consider joining our team.

You will be joining a biotech startup with long-term stability due to significant funding, but yet is very much in formation. A lot can change in this early and exciting phase, providing many opportunities for significant impact. You will work closely with a versatile team, learn a broad range of skills, and help shape insitro?? culture, strategic direction, and outcomes. Join us, and help make a difference to patients!

 Primary Responsibilities 

  • Develop, optimize, and perform cellular assays to support the Neuroscience therapeutic area.
  • Culture iPSC-derived cell-types related to your neurological models.
  • Maintain accurate documentation of experiments in electronic lab notebook (ELN) and follow all laboratory training and safety requirements
  • Evaluate and implement new enabling technologies and methodologies related to assay development and target validation packages.
  • Collaborate with colleagues on multi-disciplinary project teams to provide scientific/technical contributions and deliver project goals

 

 About You

  • A PhD with one (1) year of experience or BS/MS in Biochemistry, Cell Biology, Pharmacology or a relevant scientific field, with a minimum of five (5) years of drug discovery experience in a biotech/pharmaceutical setting
  • Familiarity with coordination and shared documentation (Gsuite, Slack, Smartsheets).
  • Experience with the development and execution of cellular assays at mid and high throughput scale, using a wide range of experimental methods and detection technologies including advanced microscopy, immunoassays (IF, ELISA, Biochemical), functional assays (Electrophysiology,  MEA, Calcium Imaging).
  • Experience in high throughput imaging and assay development from image based systems.
  • Demonstrated ability to work in cross-functional teams to advance drug discovery, with excellent organization and communication skills

Nice to Have 

  • Experience and knowledge of neurological and psychiatric disorders and in vitro models with an emphasis on epileptic, neurodegenerative, and cognitive disorders
  • Experience with analysis scripts in python, R and collaborative platforms such as jupyter notebooks.
  • Experience with molecular biology and functional genomics techniques such as CRISPR and siRNA. 
  • Hands-on experience with high throughput automated cell culture and dosing equipment (Echo, Plate washers, Certus, Hamilton, etc), interaction with automation engineers a plus.

 

Compensation & Benefits at insitro
 
Our target starting salary for successful US-based applicants for this role is $95,000 - $125,000. To determine starting pay, we consider multiple job-related factors including a candidate?? skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data. 
 
This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.
 
In addition, insitro also provides our employees:
  • 401(k) plan with employer matching for contributions
  • Excellent medical, dental, and vision coverage (insitro pays 100% of premiums for employees), as well as mental health and well-being support
  • Open, flexible vacation policy
  • Paid parental leave
  • Quarterly budget for books and online courses for self-development
  • Support to occasionally attend professional conferences that are meaningful to your career growth and development
  • New hire stipend for home office setup
  • Monthly cell phone & internet stipend
  • Access to free onsite baristas and cafe with daily lunch and breakfast
  • Access to free onsite fitness center
  • Commuter benefits
About insitro
 
insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro?? approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience, oncology and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit .